Patents held by Lemont Kier

Lemont Kier

<span style="font-size: small;"><span style="font-size: small;"> <div><strong>1. U.S. Patent 3,337,398<br /> </strong></div> </span> <div><strong><span>Method of Killing Microorganisms</span></strong><span><br /> L. B. Kier  August, 1967 <br /> <br /> ABSTRACT: The present invention relates to antibiotic activity, and  is more particularly concerned with a method of killing microorganisms by means of mesoionic 1,3,4-thiadiazoles. <br /> <br /> </span></div> <hr /> <div><strong><br /> 2. U.S. Patent 3,427,317</strong><br /> <span style="font-size: small;"><strong>Certain Pseudo Oxatriazole Derivatives </strong></span><span style="font-size: small;"><br /> L. B. Kier and J. W. Keating  February 11, 1969 <br /> <br /> ABSTRACT: A pseudo-oxatriazole having the formula </span> </div> <br /> <table cellspacing="0" cellpadding="0" border="0" align="left" width="200"> <tbody> <tr> <td style="text-align: center;">R</td> <td style="text-align: center;">—</td> <td style="text-align: center;">N</td> <td style="text-align: center;">—</td> <td style="text-align: center;">N</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> </tr> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;">|</td> <td style="text-align: center;"> </td> <td style="text-align: center;">|</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> </tr> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;">N</td> <td style="text-align: center;"> </td> <td style="text-align: center;">C</td> <td style="text-align: center;">—</td> <td style="text-align: center;">O</td> </tr> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: right;">\</td> <td style="text-align: center;"> </td> <td style="text-align: left;">/</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> </tr> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;">O</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td> </td> </tr> </tbody> </table> <br /> <br /> <br /> <br /> <br /> <br /> wherein R is an alkyl, cycloalkyl, aralkyl, alkoxyalkyl, alkaryl, alkarylalkyl, alkoxyaryl, and unsaturated alkyl (alkenyl) amino-alkyl, or heterocyclic group. The heterocyclic group includes such members as pyridyl, piperidyl, tropanyl, and pseudo-oxatriazole alkyl. The above compounds are obtained by heating a N-nitrososemicarbazide having the formula:  <div style="text-align: center;"> </div> <table cellspacing="0" cellpadding="0" border="0" width="200"> <tbody> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;">O</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> </tr> <tr> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> <td style="text-align: center;">|</td> <td style="text-align: center;"> </td> <td style="text-align: center;"> </td> </tr> <tr> <td style="text-align: center;">R</td> <td style="text-align: center;">—</td> <td style="text-align: center;">NH</td> <td style="text-align: center;">—</td> <td style="text-align: center;">N</td> <td style="text-align: center;">—</td> <td style="text-align: center;">C</td> <td style="text-align: center;">—</td> <td style="text-align: center;">NH<sub>2</sub></td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: center;">|</td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right;"> NO</td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table> <br /> wherein R has the same meaning as R above, at a temperature and for a time such as to bring out cyclization. The above pseudo-oxatriazole compounds are physiologically absorbed at an extremely fast rate. The cycloalkyl pseudo-oxatriazoles are particularly useful as central nervous system stimulants, and the aralkyl and alkyl pseudo-oxatriazoles as hypotensive agents. </span>