Curriculum Vitae for Lemont Kier Ph.D.

Lemont Kier

Education Ohio State University, B.Sc. in Pharmacy, 1954 University of Minnesota, Ph.D. 1958 (Medicinal Chemistry) <o:p> </o:p>Professional Positions <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td width="200">Assistant Professor of Medicinal Chemistry</td> <td width="100">1959-1963 </td> <td>University of Florida</td> </tr> <tr> <td>Associate Professor of Medicinal Chemistry </td> <td>1963-1966</td> <td>Ohio State University</td> </tr> <tr> <td>Associate Fellow in Medicinal Chemistry</td> <td>1966-1972 </td> <td>Battelle Institute, Columbus, Ohio</td> </tr> <tr> <td>Professor of Chemistry</td> <td>1972-1977</td> <td>Massachusetts College of Pharmacy, Boston, MA</td> </tr> <tr> <td>Department Chairman</td> <td>1972-1974</td> <td>Department of Medicinal Chemistry, Massachusetts College of Pharmacy, Boston, MA</td> </tr> <tr> <td>Division Director</td> <td>1974-1976</td> <td>Massachusetts College of Pharmacy, Boston, MA</td> </tr> <tr> <td>Department Chairman</td> <td>1977-1987</td> <td>School of Pharmacy, Virginia Commonwealth University, Richmond, VA</td> </tr> <tr> <td>Professor of Medicinal Chemistry</td> <td>1987-present</td> <td>School of Pharmacy, Virginia Commonwealth University, Richmond, VA</td> </tr> <tr> <td>Senior Fellow</td> <td>2002 – present</td> <td>Center for the Study of Biological Complexity</td> </tr> <tr> <td>Visiting Professor</td> <td>1989-2002</td> <td>University of Lausanne,Switzerland</td> </tr> </tbody> </table>                                                             Public Service Military <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td width="200">Commissioned </td> <td width="100">1954 </td> <td>2nd Lt., Medical Service Corps, U.S. Army Reserve</td> </tr> <tr> <td>Active Duty </td> <td>1958</td> <td>Ft. Sam Houston, Texas</td> </tr> <tr> <td>Active Reserve Duty </td> <td>1958-1966</td> <td> </td> </tr> <tr> <td>Retired Reserve</td> <td>1969</td> <td>Rank: Major</td> </tr> <tr> <td>Certificate of Recognition</td> <td>2001</td> <td>US Dept. of Defense, Cold War Service</td> </tr> </tbody> </table> Government <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td>Councilman   Worthington (Ohio) City Council</td> <td width="100">1966 – 1972</td> </tr> </tbody> </table>   Honors <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td>Rho Chi Pharmacy honorary fraternity </td> <td width="100">1953</td> </tr> <tr> <td>Fellow of the Academy of Pharmaceutical Sciences   </td> <td>1981</td> </tr> <tr> <td>Fellow of the American Association of Pharmaceutical Sciences </td> <td>1986</td> </tr> <tr> <td>Visiting Professor, University of Lausanne</td> <td>1989-present</td> </tr> <tr> <td>Chair of Honor, University of Lausanne</td> <td>1992</td> </tr> <tr> <td>Virginia Life Achievement Award in Science </td> <td>2004</td> </tr> </tbody> </table>   <h2>Professional Activities</h2> <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td width="200">Adjunct Professor of Medicinal Chemistry</td> <td width="100">1969-1972</td> <td>University of Michigan, Ann Arbor, MI</td> </tr> <tr> <td>Scientific Advisor</td> <td>1970-1971</td> <td>Korean Institute of Science and Technology, Department of State, Seoul, South Korea</td> </tr> <tr> <td>Chairman, Medicinal Chemistry Section</td> <td>1972-1973</td> <td>Academy of Pharmaceutical Science, APHA</td> </tr> <tr> <td>Board of Directors</td> <td>1972-1974</td> <td>International Society of Quantum Biology</td> </tr> <tr> <td>Editor</td> <td>1972-1974</td> <td>APHA Book Reviews in Medicinal Chemistry</td> </tr> <tr> <td>Editorial Advisory Board</td> <td>1980-1996</td> <td>Molecular Pharmacology</td> </tr> <tr> <td>Editorial Advisory Board</td> <td>1992-1997</td> <td>Quantitative Structure-Activity Relationships</td> </tr> <tr> <td>Editorial Advisory Board</td> <td>1992 –1994</td> <td>Medicinal Chemistry Research</td> </tr> <tr> <td>Editorial Advisory Board </td> <td>1992-present</td> <td>QSAR in Toxicology</td> </tr> <tr> <td>Board Member </td> <td>2000-present </td> <td>QSAR Society</td> </tr> </tbody> </table> <h2>Professional Societies</h2> <ul> <li>American Chemical Society</li> <li>American Association of Pharmaceutical Scientist</li> <li>American Association of Colleges of Phamacy</li> <li>QSAR Society</li> </ul> <o:p> </o:p> Virginian Commonwealth University Service <table height="20" cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td>Department Chairman  </td> <td width="100">10 years</td> </tr> <tr> <td>MCV Space Committee</td> <td>4 years</td> </tr> <tr> <td>Space Evaluation Team</td> <td>1 year</td> </tr> <tr> <td>Egyptian Building Renovation Committee, Chairman</td> <td>2 years</td> </tr> <tr> <td>VCU Governance Planning Committee</td> <td>3 years</td> </tr> <tr> <td>VCU Governance By Laws Committee, Chairman</td> <td>1 year</td> </tr> <tr> <td>Academic Computer Advisory Committee</td> <td>3 years</td> </tr> <tr> <td>Academic Computer Advisory Committee, Chairman</td> <td>1 year</td> </tr> <tr> <td>VCU Patent Committee, Chairman </td> <td>3 years</td> </tr> <tr> <td>A.D. Williams Grant-in-Aid Committee</td> <td>4 years</td> </tr> <tr> <td>Cancer Center Grant Committee </td> <td>2 years</td> </tr> <tr> <td>Search Committee, Director of MCV Computing</td> <td>1/2 year</td> </tr> <tr> <td>Search Committee, VP for Research</td> <td>1/2 year</td> </tr> <tr> <td>University Graduate Council</td> <td>13 years</td> </tr> <tr> <td>Programs/Courses Committee, Chairman                            </td> <td>8 years</td> </tr> <tr> <td>VCU Convocation Planning Committee                               </td> <td>1 year</td> </tr> <tr> <td>A.D. Williams Research Advisory Committee                      </td> <td>5 years</td> </tr> <tr> <td>VCU Faculty Handbook Committee                                   </td> <td>2 years</td> </tr> <tr> <td>VCU Promotion and Tenure Committee                              </td> <td>3 years</td> </tr> <tr> <td>VCU Promotion and Tenure Committee, Chairman             </td> <td>2 years</td> </tr> <tr> <td>VCU Promotion/Tenure By-Laws Revision Committee       </td> <td>2 years</td> </tr> <tr> <td>VCU Graduate School Development                                 </td> <td>6 years</td> </tr> </tbody> </table>   Industrial and Government Research Grants, Contracts and Consultancies <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td>NIH CY  </td> <td width="100">1961-1963</td> </tr> <tr> <td>Strassenburg Labs </td> <td>1961-1963</td> </tr> <tr> <td>NIH HE </td> <td>1962-1964</td> </tr> <tr> <td>NIH GM</td> <td>1965-1967</td> </tr> <tr> <td>NIH AI </td> <td>1966-1968</td> </tr> <tr> <td>Miles Labs  </td> <td>1967</td> </tr> <tr> <td>Mead Johnson</td> <td>1968</td> </tr> <tr> <td>Abbott Labs  </td> <td>1968</td> </tr> <tr> <td>NIH GM </td> <td>1968-1974</td> </tr> <tr> <td>Bristol Meyers</td> <td>1969</td> </tr> <tr> <td>A. H. Robins</td> <td>1969-1970</td> </tr> <tr> <td>Norwich Pharmacal </td> <td>1972</td> </tr> <tr> <td>NIMH DA</td> <td>1975-1979</td> </tr> <tr> <td>Dynapol Co.</td> <td>1979-1980</td> </tr> <tr> <td>EPA </td> <td>1981-1984</td> </tr> <tr> <td>Gruppo-Leppitet (Italy) </td> <td>1983</td> </tr> <tr> <td>Mitre Corp </td> <td>1984-1985</td> </tr> <tr> <td>Eastman Kodak </td> <td>1987</td> </tr> <tr> <td>U.S. Army Chem. Res.</td> <td>1988-1991</td> </tr> <tr> <td>Allied Signal </td> <td>1987</td> </tr> <tr> <td>Sterling Research Inc. </td> <td>1989-1994</td> </tr> <tr> <td>DuPont Pharmaceutical </td> <td>1994</td> </tr> <tr> <td>Ares Sorono </td> <td>1996,1999</td> </tr> <tr> <td>SciVision/Academic Press  </td> <td>1998-present</td> </tr> <tr> <td>U. S. Dept. of Ed.</td> <td>2000-2001</td> </tr> </tbody> </table>      Graduate Students/Post-Doctoral Fellows/Sabbatical Fellows <table cellspacing="3" cellpadding="3" width="700" border="0"> <tbody> <tr> <td>K. K. Kaistha</td> <td>Ph.D. </td> <td width="100">1962</td> </tr> <tr> <td>D. Dhawan</td> <td>Ph.D. </td> <td>1963</td> </tr> <tr> <td>T. Stewart</td> <td>Ph.D.</td> <td>1964</td> </tr> <tr> <td>E. Roche</td> <td>Ph.D.</td> <td>1968</td> </tr> <tr> <td>H. Aldrich (USA) </td> <td>Postdoctoral </td> <td>1973</td> </tr> <tr> <td>H.-D. Holtje (Germany)  </td> <td>Postdoctoral </td> <td>1974 </td> </tr> <tr> <td>T. DiPaolo (Canada) </td> <td>Postdoctoral </td> <td>1975 </td> </tr> <tr> <td>W. Murray (USA) </td> <td>Sabbatical Fellow </td> <td>1976 </td> </tr> <tr> <td>L. Hall (USA) </td> <td>Sabbatical Fellow </td> <td>1976 </td> </tr> <tr> <td>S. Tovivich  </td> <td>M.S. </td> <td>1976 </td> </tr> <tr> <td>M. Tute, (England)</td> <td>Sabbatical Fellow</td> <td>1976</td> </tr> <tr> <td>M. Lund </td> <td>M.S.</td> <td>1981</td> </tr> <tr> <td>S. Baldwin, (USA)</td> <td>Postdoctoral </td> <td>1981</td> </tr> <tr> <td>U. Kim, (Korea) </td> <td>Sabbatical Fellow</td> <td>1982 </td> </tr> <tr> <td>G. Szasz, (Hungary)</td> <td>Sabbatical Fellow </td> <td>1983</td> </tr> <tr> <td>D. Bonchev, (Bulgaria) </td> <td>Sabbatical Fellow</td> <td>1990</td> </tr> <tr> <td>A. T. Balaban, (Romania)</td> <td>Sabbatical Fellow</td> <td>1991</td> </tr> <tr> <td>N. Joshi, (India)</td> <td>Ph.D.</td> <td>1993</td> </tr> <tr> <td>C. De Gregorio, (Spain)</td> <td>Graduate Student </td> <td>1997</td> </tr> <tr> <td>G. Gunnarsson, (Iceland)</td> <td>Graduate Student </td> <td>1998</td> </tr> <tr> <td>P. Seybold (USA)</td> <td>Sabbatical Fellow</td> <td>2004</td> </tr> </tbody> </table>   <h2>Course Lectures</h2> <h3>Pharmacy Students</h3> <ul> <li>Elements of drug design </li> <li>Diuretics </li> <li>NSAID’s </li> <li>Opioid Analgesics </li> <li>CNS Depressants </li> <li>Selected Herbal Remedies <o:p> </o:p></li> </ul> <h3>Nurse Anesthesia Students</h3> <ul> <li>Chemical structure and bonding</li> <li>Drug-receptor interactions</li> <li>General Anesthetics</li> <li>NSAID’s</li> <li>Opioid Analgesics</li> <li>Sedatives/Hypnotics</li> <li>Anticonvulsants</li> </ul> <o:p>  </o:p>Graduate Program <ul> <li>Principals of drug design</li> <li>Structure-Activity concepts</li> <li>Physical property descriptors</li> <li>Molecular connectivity descriptors</li> <li>Kappa shape and flexibility descriptors</li> <li>Electrotopological state descriptors</li> <li>Molecular orbital theory</li> <li>Data selection</li> <li>Database management</li> <li>Complexity and emergence</li> <li>Cellular automata studies</li> </ul> Invited Presentations at National and International Symposia <ol> <li>Buffalo, New York - August, 1968.  Buffalo-Milan Symposium On Molecular Pharmacology. "Receptor Mapping Using Molecular Orbital Theory."</li> <li>Seattle, Washington - October, 1969.  Battelle Symposium On Quantum Pharmacology.  "Molecular Orbital Considerations Of Aminoacid Conformation."</li> <li>Richmond, Virginia - November, 1969.  S. E. Regional American Chemical Society Meeting.  "Molecular Orbital Calculations Of Preferred Conformation."</li> <li>Toronto, Canada - May 1970.  C.I.C.-A.C.S. Meeting.  "Molecular Orbital Studies Of Drug Molecule Conformation." </li> <li>Menton, France - July, 1970.  International Colloquim On Quantum Chemistry. "Quantum Pharmacology: Molecular Orbital Studies Of Drug Molecule Conformations", plus seminars at  Battelle Frankfort and Battelle Geneva. </li> <li>Chonju, Korea - November, 1970.  Korean Chemical Society.  "Molecular Orbital Theory In Drug Research.”</li> <li>Los Angeles, California - April, 1971.  Pesticide Division, American Chemical Society.  "Molecular Orbital Studies Of Drug And Hormone Molecule Conformation." </li> <li>Cincinnati, Ohio - June, 1971.  Central Regional Meeting, American Chemical Society.  "Molecular Orbital Considerations In Conformational Specificity." </li> <li>Andover, New Hampshire - July, 1971. Gordon Conference On Molecular Pharmacology. "Extended Huckel Calculations On Acetylcholine." </li> <li>Burlington, Vermont - August, 1971.  American Society For Pharmacol. & Exp. Ther. And Division Of Medicinal Chemistry, A.C.S. "Molecular Orbital Studies Of Conformation And Physiological Activity In The Prostaglandins." </li> <li>New Orleans, Louisiana - February, 1972.  American Chemical Society Mardi Gras Symposium.  "Molecular Orbital Studies of Biological Molecule Conformations." </li> <li>Milan, Italy - September, 1972.  International Symposium On Medicinal Chemistry.  "The Prediction Of Molecular Conformation As A Biologically Significant Property." </li> <li>London, England - September, 1972.  Society For Drug Research, Conference On Conformation And Drug Action. “Drug Conformation Calculated By Molecular Orbitals”</li> <li>Cambridge, Massachusetts - December, 1972.  N.  E. Regional Meeting, Medicinal Chemistry Division, A.C.S.  "Molecular Orbital Studies Of Drug Molecules."</li> <li>Prague, Czechoslovakia - June, 1973.  Conference On Structure-Activity Relationships.  "Molecular Orbital Predictions Of Properties Influencing Biological Phenomena." </li> <li>Stockholm, Sweden - September, 1973.  Federation Internationale Pharmaceutique.  "Molecular Orbital Studies In Chemical Pharmacology." </li> <li>Noordwijkerhout, Netherlands - September, 1974. International Symposium On Medicinal Chemistry. "SAR Studies On GABA-Like Agents." </li> <li>Wadenswil, Switzerland - September, 1975.  European Chemoreception Research Organization.  "Theoretical Studies On The Sweet-Taste Glucophore." </li> <li>Atlanta, Georgia - November, 1975.  Academy Of Pharmaceutical Sciences.  "Molecular Connectivity In Drug Research." </li> <li>Gregynog, Wales, U. K. - May, 1976.  European Symposium On Bioorganic Chemistry.  "Theoretical Approaches To Drug SAR Studies." </li> <li>Namur, Belgium - May, 1976.  International Symposium On  Drug-Receptor And Drug-Enzyme Interactions.  "Molecular Connectivity In Chemistry And Drug Research." </li> <li>Hollywood, Florida - November, 1978.  Academy Of Pharmaceutical Sciences Symposium On Methods In SAR.  "Molecular Connectivity In Drug Research." </li> <li>Kyoto, Japan - August, 1982.  Fifth International Congress Of Pesticide Chemistry.  "Recent Advances In Molecular Connectivity Analysis Of Biological Molecules."  </li> <li>Portoroz, Yugoslavia Sept. 1986.  Sixth European Conference on QSAR.  "Molecular Shape from Chemical Graphs."   </li> <li>Interlaken, Switzerland 1988. Seventh European Conference on QSAR."Flexibility Quantitation."</li> <li>Lausanne, Switzerland  March 1995. Lipophilicity Symposium "A Cellular Automata Model of Partitioning".</li> <li>Valencia, Spain June 1997 “Molecular Connectivity  Difference Indices” Girona, Spain 1999  "The E-State Indices in Similarity Searching"</li> <li>Washington, D. C. 2000, Am. Chem. Soc., 25th Anniv. Symposium on Molecular Connectivity “The Meaning of Molecular Connectivity”</li> </ol>